Kalman syndrome is hypogonadotropic hypogonadism, which is better treated with long-term regular drug replacement therapy; during the initiation and developmental stages of puberty, gonadotropin or testosterone therapy can be used to promote and complete the pubertal development process; during the reproductive years, gonadotropin replacement therapy can be used to restart testicular spermatogenesis, ideally leading to natural conception and fertility, and after treatment if If the semen quality does not meet the requirements for natural fertility, artificial insemination or IVF assisted fertility can also be used; artificial insemination or in vitro fertilisation-embryo transfer assisted fertility techniques are found and used when necessary to aid conception.