Cardiac depression and chest tightness is a relatively common clinical condition. The main causes of cardiac depression and chest tightness are coronary heart disease, anemic heart disease, hyperthyroidism, pericarditis, myocarditis, cardiomyopathy, arrhythmia, cardiac insufficiency, and cardiac neuropathy. There are some differences in the conditions of the above diseases and therefore in their treatment. For patients with cardiac depression and chest tightness, further definitive diagnosis must be made. Patients must first be examined for cardiovascular and respiratory disease, i.e., electrocardiogram, color Doppler ultrasound, and lung x-ray to rule out heart or lung disease, and then consider whether there is a problem of emotional agitation, which when depressed may manifest as chest tightness, shortness of breath, and frustration, for which psychological counseling is required. In order to make a detailed assessment of mood and to determine whether there are symptoms of depression, anxiety, or nervousness, patients should seek prompt medical attention and treat the symptoms after a detailed examination.