Rheumatoid arthritis is closely related to the infection of group A type B hemolytic streptococcus, and its therapeutic drugs mainly include penicillins, which play the role of anti-infection, and non-steroidal anti-inflammatory drugs and glucocorticoids, which play the role of anti-rheumatism. 1. Anti-infective treatment: the onset of rheumatoid arthritis is closely related to the infection of group A beta-hemolytic streptococcus, so rheumatoid arthritis patients need to remove the infected foci through anti-infective treatment, the commonly used drugs are benzylpenicillin as the representative of penicillin drugs, patients allergic to this kind of drugs can also choose roxithromycin, lincomycin, and cephalosporins and other drugs for treatment. 2. Anti-rheumatic therapy: anti-rheumatic therapy commonly used drugs include glucocorticosteroids and non-steroidal anti-inflammatory drugs, glucocorticosteroids, including prednisone, methylprednisolone, etc., non-steroidal drugs, including indomethacin, lorsoprofen sodium, and so on. Drugs need to be used under the guidance of a physician, it is recommended that patients to the rheumatology and immunology department of the regular hospital for consultation, follow the doctor’s instructions to take medication.