It is possible to jerk off after taking amoxicillin, and it will not affect masturbation. Amoxicillin is a penicillin antibiotic with strong antibacterial effects, mainly used to treat infections of the respiratory system, urinary tract and skin infections, so it does not affect sexual life or masturbation. However, it should be noted that if the medication is taken to treat inflammation of the male reproductive system infection, patients are advised to avoid jerking off or having sex as much as possible to avoid aggravating the primary disease.