Drinking alcohol the day before vaccination is not an absolute contraindication to vaccination, but it is not recommended to drink alcohol the day before vaccination. Due to the short interval, if the amount of alcohol consumed is large or the degree of alcohol consumed is high, it may lead to the incomplete metabolism of alcohol in the body and the presence of certain residues in the body, which may affect the immune system of the body, thus affecting the vaccine effect and possibly aggravating the adverse reactions after vaccination.1, affecting the vaccine effect: the incomplete metabolism of alcohol may affect the immune system of the body. It may affect the immune response of the body after the new crown vaccine, resulting in poor vaccination effect or even ineffectiveness, and the body still has the risk of disease; 2. Aggravating adverse reactions: adverse symptoms such as fever and dizziness may occur after the new crown vaccine, which are common phenomena that may occur after vaccination. Alcohol residues in the body may stimulate the organism to aggravate the adverse reactions, or may mask the adverse reactions produced by the organism, leading to misdiagnosis and adverse effects on the health of the organism. It is also not recommended to drink alcohol for a short period of time after the completion of vaccination with the new crown vaccine, as it may also affect the effectiveness of the vaccine or aggravate the adverse reactions after vaccination. If symptoms such as severe headache, dizziness, vomiting or diarrhea occur and are not relieved after rest, it is recommended to go to the hospital for examination.