In the battle against disease for survival, epidemiology was gradually formed and developed, so its history is a history of blood and tears! Let’s introduce some historical stories about the origin. Cholera, smallpox, and bubonic plague had many pandemics around the world. When smallpox was prevalent in the Song Dynasty, people invented the pox inoculation method to stop the natural infection of smallpox. In the Ming Dynasty, Wu Youxian wrote “Treatise on the Warm Epidemic” in 1642, which was the first medical book to systematically study acute infectious diseases in China. However, strictly speaking, in ancient China, there was only epidemiological thinking, but no epidemiological system, and epidemiology was a foreign monk who could recite scriptures! It must be mentioned is that in 1831-32, cholera occurred in England created the famous “Snow investigation”. During the cholera, the workers in the brewery did not get sick. After Snow’s investigation, it was confirmed that the workers used alcohol instead of water, thus saving them from contracting the disease by contaminating the water. In 1850, with the establishment of the “Epidemiological Society of London”, epidemiology was formally established as a discipline. What does epidemiology do for food What does epidemiology do? So far, epidemiology has gone through three periods of development, each relying on different skills to make a living. The first period was the era of public health, and public health programs were the main measure of disease prevention during this period. As mentioned earlier, John Snow, a British physician in the early 19th century and one of the founders of modern epidemiology, creatively used dotted maps to reveal the transmission routes of cholera; the late 19th century to the early 20th century can be considered the second period of development, where epidemiology gradually formed and refined the “three links” (infectious agents, transmission routes, susceptible populations) and two factors (social factors, natural factors) as the core. The “epidemiological process theory” with three links (source, transmission route, susceptible population) and two factors (social factors, natural factors) as the core was gradually developed and refined. Modern epidemiology began in the 1990s, which is the third stage of development. The scope of research has gradually expanded from the small environment of biology, drugs, diet, occupation and environment to the large environment of psychology, society, behavior, genetics and ecology, showing a trend from group to individual and even molecular level. The initial epidemiology was mainly focused on infectious diseases, but the contemporary development has not only been limited to this, but also extended to include many contents such as food and nutrition. The plague came out of nowhere and had to be plucked and vaccinated. The Justinian plague, which swept through the famous Byzantine Empire, influenced the course of European development. Historically, the Black Death shook the Church in Europe and changed the pattern of European rule. The plague, too, has left a strong presence in our history, directly influencing dynastic rule and regime change. The plague also had a direct impact on the public psyche, causing a crisis of faith and confusion of thought, and gave the stage to anti-science and pseudo-science, and some rumors and cults have made their debut, and you have sung and I have sung. Today’s Western hedonistic ideology, the human attitude of getting drunk today, also originated from the great plague that ravaged European history. Plague is a matter of political stability, economic development and social harmony, so preventing, controlling and treating plague is not only a matter of medicine, but also a matter of the whole planet. Although today Google and other internet sages have resorted to big data platforms to predict disease epidemics. However, even predicting influenza has not yet been successful, let alone many diseases that are unheard of to the public. The occurrence, development and prevalence of diseases have so many unknown influences that many of them are difficult to predict in advance. Simply put, catastrophes and major wars must be followed by pandemics, but how can catastrophes and major wars be predicted successfully and easily? Therefore, hindsight is a must. And for the treatment of diseases, one must mention vaccines. Vaccines are a work of genius with mileage. What is a vaccine? A vaccine is like TMD, not a curse, but a Theater Missile Defense System (TMD). How does a ballistic missile defense system counter a missile? It has to study the characteristics of the missile, analyze its trajectory and destructive power, and then use a specific missile to counter its destructive power. To create a vaccine, it is necessary to obtain and understand the pathogen, study its destructive power, and then tailor it to create an antibody that targets the source of the disease. This antibody is the missile that hits the missile. Are we too late to make a vaccine? Objectively speaking, it is not too late. To make a vaccine, you first need to obtain the pathogen, and then use the pathogen to make the vaccine. However, diseases are often not known how they came to be, but only seen how they are not. The time left for medical doctors to analyze diseases and research vaccines is extremely limited due to the difficulty of being identified early. In fact, the disease comes like a mountain, and if it spreads rapidly, it must be pulled out. Through the transgenic approach, industrial mass production by microorganisms working instead of humans has now been achieved. This is like Apple and Foxconn factories. Foxconn’s strong factory capacity can guarantee the mass market and sales of new Iphone phones. However, the renewal of Apple’s cell phone ultimately depends on Apple’s R&D, and has little to do with Foxconn’s production capacity. The same is true for vaccines. It is difficult not to cut down trees, but to plant them. With the times of the pathogens, we can not afford to mess with anyone. The world is evolving rapidly, and pathogens are not idle. The evolutionary instinct is well reflected in pathogens, through mutations at the genetic level, to achieve the Pancreatic badger information around the martyr’s heart Suwa’s “old” SARS, to HxNx flu, to today’s Ebola virus, each epidemic is caused by mutations. And the big problem that arises is that you have a disease, I have no medicine, although it is only temporary! The disease is rampant, every minute is a life and death situation. I remember a news story about a man who developed super-resistant bacteria from long-term antibiotic use, which is an extreme case of pathogen resistance. It is because of antibiotic abuse that patients are facing the situation of “no cure”. Once the pathogens have evolved and become resistant, our existing drugs are “obsolete”. This is the era of advancement, but also the era of backwardness; this is the spring of hope, but also the winter of helplessness. Everything depends on people themselves, pathogens play with the times, we rely on scientific development.