HDL cholesterol is also known as “good cholesterol” and doctors often recommend that plasma HDL levels should be higher than 1.04 mmol/L. However, higher HDL is not better because high HDL may also be associated with inflammatory diseases, certain medications and abnormal thyroid function. Specific details are as follows: 1. Inflammatory diseases: Chronic hepatitis, primary biliary cholangitis and other diseases may have high HDL, which is due to abnormal liver function, resulting in abnormal lipid metabolism. 2, certain drugs: some drugs may increase HDL levels, and these drugs often also have the effect of reducing LDL cholesterol, triglycerides, and total cholesterol, including: (1) bile acid sequestrants, i.e., drugs that inhibit the absorption of lipids in the diet. (2) Cholesterol absorption inhibitors. (3) omega-3 unsaturated fatty acids: increase HDL levels while decreasing triglycerides. Statins: prevent liver tissue from synthesizing more cholesterol. (3) Abnormal thyroid function: Thyroid hormone has a regulatory role in lipid metabolism, and hypothyroidism can cause an increase in HDL.