Spider bites were rarely heard of in the past and are not even described in detail in textbooks, but in recent years, I have often encountered patients in my clinical practice who have been bitten by spiders, often for several days, and whose condition is serious enough to require hospitalization. Spiders are found all over the world and feed on insects, most of which are beneficial and a few of which bite humans. Spiders often live in hidden places such as dark rooms, closets, cellars, woodpiles, toilets, and under the eaves of houses. In summer and autumn, they crawl into clothes, pants, shoes and socks and cause harm to humans when it is hot. Pathogenesis: The spider’s body is divided into two parts: the head and thorax and the abdomen. The head has a pair of stinging limbs with fine fangs at the end, which are connected to the poison glands in the body. Spider venom contains a variety of toxins, including neurotoxins, hemolytic toxins and hyaluronidase-like factors. Neurotoxins cause local pain, vomiting, and muscle spasms, while hemolysis toxins and hyaluronidase-like factors cause intimal thickening, local necrosis, hemolysis, and in severe cases, renal failure. Clinical manifestations: The human body shows two kinds of reactions after the spider bite, one is limited and the other is systemic. 1, limited type: that is, necrotic skin type, the skin appears a large area of gangrene, the first 8 hours of significant painful edema, followed by large blisters, surrounded by erythema, with local ischemia. After about a week, the central damage becomes black and well-defined, gangrene occurs, and a huge necrotic ulcer several centimeters wide may be formed, which remains untreated for several months. 2. Systemic type: a rare visceral-skin type. In addition to the same localized lesions, the patient presents with a high temperature of 39-40°C, chills, vomiting, arthralgia and hematologic manifestations, hematuria usually appearing in 1 day, with hemolytic anemia, thrombocytopenia and other cachectic manifestations, petechiae or a measles-like rash on the skin. Death. Treatment: 1, ice, local compression, elevate the affected limbs, pay attention to rest; 2, systemic application of glucocorticoids anti-inflammatory and anti-allergic, broad-spectrum antibiotics anti-infective treatment, aspirin antiplatelet coagulation to prevent deep vein thrombosis; systemic symptoms alleviated after the necrosis of the local can be surgical treatment; 3, Chinese medicine treatment: external use of snakebite or three yellow ointment, the treatment should be clear heat and cool the blood, the party selected Xianfang live drink plus reduction. Prevention: 1, try not to go to shady places; 2, when dressing, you can first shake the clothes a few times; 3, pay attention to the environmental hygiene in the room, keep the room ventilated and dry.