1.Drain the urine in the bladder before instillation, drink less water before instillation to avoid dilution of the drug by urine. 2, position: supine, right lateral, prone, left lateral position, average time then urinate. 3, the course of treatment: once a week infusion a total of 8 times, counting 2 months; after once a month infusion a total of 10 times, counting 10 months, a total of 1 year. 4, drug perfusion should pay attention to the principle of aseptic operation, before and after perfusion can be prophylactic oral antibiotics. 5.If urinary frequency, urinary urgency, urinary pain occurs, urinary routine can be rechecked, drug treatment, and suspension of bladder instillation treatment in severe cases. 6.After emptying the medicine, you can drink more water.