Medication for fibroids is only suitable for women with mild clinical symptoms or near menopause. Since the cause of fibroids is related to female sex hormones, commonly used medications are hormone analogs that counteract estrogen and progesterone, such as gonadotropin-releasing hormone analogs or mifepristone. The gonadotropin-releasing hormone analogs can lower estrogen to postmenopausal levels, which can relieve symptoms such as increased menstrual flow or prolonged periods caused by leiomyosarcoma, and inhibit the growth of leiomyosarcoma to make it shrink, but after stopping the medication, the leiomyosarcoma will gradually increase to its original size again. However, after stopping the medication, the fibroids gradually grow back to their original size. Long-term use of the medication may cause side effects such as irritability and insomnia, hot flashes and sweating, and menopausal syndrome, and osteoporosis. These medications are often used for preoperative treatment of leiomyosarcoma to control symptoms, correct anemia, and reduce the size of leiomyosarcoma to make surgery less difficult. Commonly used drugs include leuprolide, goguirelin, etc. Mifepristone is also commonly used in the treatment of fibroids, mainly as a preoperative drug or as a drug for early menopause. Like gonadotropin-releasing hormone analogs, long-term use is not recommended. Mifepristone can antagonize progesterone to inhibit the growth of fibroids, but it can lead to long-term estrogen stimulation of the endometrium, thus increasing the risk of endometrial hyperplasia. Uterine fibroids without obvious symptoms can be treated without special treatment, and ultrasound should be reviewed regularly. Surgery to remove fibroids is the most effective treatment, but medication is recommended for those with mild symptoms, near menopause, or whose general condition does not allow surgery. However, medication should not be used for a long time. If there is no significant effect of medication, it is recommended to go to the hospital for further examination and surgical treatment.