The weakness of the whole body after taking the quadruple drug may be an adverse reaction to the drug, or liver disease, hypothyroidism and other diseases, if the symptoms are not very serious can continue to use the drug treatment, if the symptoms are more serious can be considered to change the drug treatment. Quadruple drugs ate general weakness may be considered to be caused by adverse reactions to drugs, for example, amoxicillin medication may cause anemia, then lead to symptoms of fatigue, if the symptoms can be tolerated can continue to use the drug treatment; however, if the symptoms are more serious consider replacing the drug treatment. In addition, generalized weakness can also be caused by liver disease, hypothyroidism and other diseases, liver disease such as cirrhosis can use reduced glutathione and other hepatoprotective drugs; hypothyroidism can take levothyroxine sodium tablets. Quadruple drugs eat the whole body weakness, there may be other reasons, if the symptoms are more serious recommended to go to the hospital, consult a professional doctor.