In clinical practice, headache is a very common clinical phenomenon and many diseases may cause headache. In this case, it is necessary to promptly identify the relevant causes and apply a series of drugs to relieve the clinical manifestations of headache and reduce the patient’s pain. The clinical examination should be followed by symptomatic treatment, such as proper examination of the external surface of the scalp for pustules or abscesses, subcutaneous fluid, scalp hematoma, etc., and whether it is accompanied by numbness and weakness of the limbs, speech dysfunction or even epilepsy. The next step is imaging, head CT, head MRI, and even cerebral angiography, which can clarify the relevant pathological factors, and if it is an organic lesion, we must continue to improve the relevant examination to clarify the basic pathological nature. Next is the symptomatic treatment measures, generally speaking, the most common is to take the relevant oral medication for relief, such as loxoprofen, acetaminophen for treatment, also can take oral oxaliplatin tablets and so on, but also need to look at the intracranial situation, caused by cerebral edema, also can be intravenous mannitol, if the migraine attack, also can take oral flunarizine hydrochloride. Therefore, there are two kinds of treatment: treatment of the cause and symptomatic treatment, which must be done with both hands, so that the disease can be treated at the root.