Multiple nodules in both lungs with symptoms of chest tightness and shortness of breath may be caused by tuberculosis, pneumoconiosis, lung metastases and other related diseases, which can be treated according to the corresponding diseases. Besides, shortness of breath may not be related to multiple nodules in both lungs, so we need to look for other causes of shortness of breath and treat them accordingly. 1. Tuberculosis: disseminated tuberculosis can cause multiple nodules in the lungs, which can be manifested as fever, night sweats, chest tightness and shortness of breath. The treatment should be standardized anti-tuberculosis treatment, such as isoniazid, rifampicin, pyrazinamide and so on. 2. Pneumoconiosis: excessive inhalation of dust caused by occupational factors can form multiple nodules in the lungs, which can lead to the formation of pulmonary fibrosis in severe cases. Patients may have cough, sputum, chest tightness, dyspnea and other symptoms. For treatment, oxygen inhalation, use of drugs such as hanfengji methanol, and alveolar lavage can also be carried out. 3. Lung metastases: Tumors from other parts of the body metastasize to the lungs, which may also be manifested as multiple nodules. If the lesions are extensive, patients may have cough, sputum, chest tightness, breathlessness, hemoptysis and clinical symptoms of primary tumor. It is necessary to treat the primary tumor. 4. Other diseases: chest tightness and shortness of breath may be caused by chronic obstructive pulmonary disease, coronary heart disease and other diseases, which need to be actively treated. If patients with multiple nodules in both lungs have chest tightness and shortness of breath, it is recommended to consult the doctor in time, complete the examination, clarify the cause of the disease, and follow the doctor’s instructions for treatment, so as to avoid delaying the condition.