Elevated blood pressure may be related to neuroendocrine disorders. During sleep, sympathetic excitability decreases, vagal tone increases, blood pressure level decreases and heart rate slows down. When you stay up late because you can’t get timely rest, the sleep pattern is disturbed, which will lead to the night sympathetic nerve excitation, indirectly lead to the contraction of the peripheral small arteries, the rise in blood pressure. Staying up late also affects the body’s metabolism or endocrine system, leading to an increase in the level of hormones in the body that elevate blood pressure, resulting in an increase in blood pressure levels. Regularly staying up late for a long period of time may lead to an indirect increase in blood pressure, which may turn into a persistent increase and eventually develop into hypertension. People with elevated blood pressure after staying up late should pay attention to rest, ensure sufficient sleep, and strengthen the monitoring of blood pressure, if necessary, under the guidance of a physician to give treatment.