Some children are found to have darker skin than normal newborns after birth, especially in the genital area, and often have difficulty feeding, vomiting, diarrhea, and dehydration after birth; some may even find that they cannot tell whether they are boys or girls from the appearance of their external genitalia; if left untreated, this can cause precocious puberty in boys or masculinization in girls; in severe cases, this can even In serious cases, death can even occur. It is possible that congenital adrenocortical hyperplasia is the cause of these conditions. This is a congenital genetic disease in which both parents carry the gene that causes the disease but do not necessarily show signs of the disease, but the child’s condition can be very serious because these children are born with a genetic defect that makes their bodies lack an enzyme involved in adrenocortical hormone synthesis, resulting in an impairment of adrenal glucocorticoid synthesis and causing a deficiency of adrenocortical hormones in the body. Although sometimes the child’s diarrhea and dehydration can be improved after general rehydration and anti-diarrheal treatment, similar conditions often recur, parents should pay attention to this and take the child to a large hospital for diagnosis and treatment. For children who are found to have an unclear appearance after birth, parents should not be shy about seeking medical advice, but should seek medical attention in a timely manner so as not to cause irreparable lifelong regrets to their children due to untimely diagnosis and treatment. Early detection and treatment of this disease can achieve satisfactory results, the clinical often use adrenocorticotropic hormone oral replacement therapy, easy to do, proper treatment, the child can live like a normal person.