There is no direct correlation between blistering (blistering) after liquid nitrogen freezing of plantar warts and spraying with antiseptic solution. The antiseptic spray only prevents infection and does not prevent blistering. Plantar warts are prone to blistering after freezing, but may only need to be sterilized if they are not severe. Blister formation and severity are related to the intensity of freezing, and blisters usually form within 24 hours. Mild cases can be left untreated with disinfection and protection. For larger blisters or blood blisters, the blister fluid should be extracted under sterile conditions, which can significantly reduce the patient’s swelling, and at the same time pay attention to the protection of the wound to avoid bacterial infection. After liquid nitrogen freezing metatarsal warts, if there is any discomfort, it is recommended to go to the hospital in time.