Mycobacterial infection can not be used during menstruation, because the cervical opening is open during menstruation, during the release of the drug will easily bring bacteria into the female uterine cavity, causing inflammation of the uterus and even the pelvis. When the medicine is administered vaginally, the menstrual blood will wash out the medicine when the menstruation comes, thus affecting the effect of the medicine. If it is a mycotic infection during menstruation, you can take itraconazole or fluconazole under the guidance of a doctor, which are also antifungal drugs and are more effective against mycotic infections. You can wait until your period is completely clean before vaginal medication, and sanitary napkins must be changed regularly during menstruation.