Multiple metastases in pleura after lung cancer surgery belongs to advanced stage of lung cancer, and chemotherapeutic drugs, targeted drugs and immunotherapy are mainly used. 1. Chemotherapeutic drugs: patients with advanced lung cancer who can tolerate chemotherapy can choose cisplatin, carboplatin, gemcitabine, pemetrexed, paclitaxel, docetaxel and other drugs to carry out chemotherapy. The specific choice of chemotherapeutic drugs and chemotherapeutic regimen should be carried out in accordance with the doctor’s instruction, as chemotherapy can reduce the metastasis of the pleura, reduce the tumor load of the organism, and prolong the patient’s survival period. 2. Targeted drugs: Targeted drugs can inhibit tumor growth by specifically blocking the target of tumor growth. Commonly used targeted drugs include erlotinib, gefitinib, ositinib, etc. Genetic testing should be done to screen the specific target population before targeted therapy, and appropriate targeted drug therapy can significantly prolong the survival of patients with advanced disease. 3. Immunotherapy: PD-L1 test is recommended, such as pembrolizumab, sindilizumab, treprotilizumab, etc. Patients with multiple metastases in pleura after lung cancer surgery need to go to the hospital in time and choose appropriate drug treatment under the guidance of doctors to avoid further progress of the disease.