Hypothyroidism, {hypothyroidism for short}, is a systemic hypometabolic syndrome caused by various causes of hypothyroidism or thyroid hormone resistance, and is characterized by the accumulation of mucopolysaccharides in the tissues and skin, manifesting as mucinous edema. The prevalence of the general population is 0.8%-1.0%. Clinical manifestations】 1. General manifestations Easy fatigue, fear of cold, weight gain, memory loss, unresponsiveness, drowsiness, mental depression, constipation, menstrual irregularities, muscle cramps, etc. Physical examination shows indifferent expression, pale face, dry and cold skin, coarse and bad debridement, puffy skin on face, eyelids and hands, hoarse voice and thinning hair. 2. Muscles and joints Muscle weakness, temporary muscle ankylosis, spasm, pain, progressive muscle atrophy in chewing muscles, sternocleidomastoid, quadriceps and hand muscles. 3.Cardiac system Due to mucus water species resulting in myocardial contractility damage, bradycardia, and decreased cardiac blood output. ECG low voltage. Enlarged heart due to interstitial myocardial edema, non-specific myocardial fiber swelling, left ventricular dilatation and pericardial effusion. Coronary artery disease is highly prevalent in this species. angina pectoris is reduced in hypothyroidism but can be aggravated by eugenol therapy. 10% with hypertension. 4. Hematologic system Anemia occurs due to the following four causes: 1 impaired hemoglobin synthesis due to thyroid hormone deficiency; 2 iron deficiency due to impaired intestinal absorption of iron; 3 folic acid deficiency due to impaired intestinal absorption of folic acid; 4 pernicious anemia, which is an organ-specific autoimmune disease associated with autoimmune thyroiditis. 5, digestive system Anorexia, abdominal distension, constipation, paralytic intestinal obstruction or mucinous edema megacolon in severe cases. 6.Endocrine system Women have excessive menstruation or amenorrhea. Long-term severe cases may lead to pituitary hyperplasia and enlarged butterfly saddle. Some patients have increased serum trehalosin levels and overflow of breast milk. Primary hypothyroidism with idiopathic hypoadrenocorticism and type 1 diabetes mellitus is a type of multiple endocrine gland autoimmune syndrome, called SCHMIDT syndrome. [Diagnosis] Primary hypothyroidism can be established when serum TSH is increased and FT4 is decreased. If serum TSH is normal and FT4 is decreased, pituitary or hypothalamic hypothyroidism can be considered, and TRH test is needed to differentiate. Treatment】 This disease is generally not curable and requires lifelong replacement therapy. The dose of Eugenol should be adjusted by rechecking FT3, FT4 and TSH after 1 month until the best effect is achieved.