The only phrase inside the principle of antibiotic treatment for severe infections is to hit hard, to cover all the bacteria with the strongest antibiotics that can destroy them all in the shortest time. But not the best antibiotic is the best treatment for the patient. Often, after controlling the appropriate symptoms, the top antibiotics will definitely be brought down, called descending ladder treatment. In addition to heavy-handed, comprehensive coverage and step-down therapy, adequate courses of treatment and adequate amounts of antibiotics are all important for severe infections. But the use of antibiotics does not have to be used for all infections as it is said everyday, because there are many types of antibiotics that can be anti-bacterial, anti-viral, and anti-fungal. If a serious infection is caused by a virus, antibiotics should be used only for viral infections, not for bacterial or fungal infections. If the severe infection is due to coccus based on culture, anti-coccus drugs will definitely be used when antibiotics are administered and no other drugs will be used. A state like this requires that serious infections are always tested for pathogenesis before antibiotics are used.