The drugs prohibited for patients with severe hepatic insufficiency are antibiotic drugs, hormone drugs or toxic drugs. 1. Antibiotic drugs: cefoperazone sodium, oxytetracycline tablets, tetracycline hydrochloride tablets and so on. The use of cefoperazone sodium in patients with severe hepatic insufficiency may lead to elevated aminotransferases and trigger coagulation disorders. Use of hygromycin tablets may lead to hepatocellular necrosis and lethal fatty liver. The use of tetracycline hydrochloride tablets may cause fatty degeneration within the liver. 2. Hormonal drugs: hexestrol propionate tablets, methimazole tablets, methyltestosterone tablets and other hormonal drugs. The use of hormonal drugs in patients with severe hepatic insufficiency aggravates the burden on the liver and leads to further deterioration of the condition. 3. Toxic drugs: cytarabine, penicillamine, trimethoprim and other toxic drugs. The use of toxic drugs in patients with severe hepatic insufficiency will affect the release of certain drug toxicity, leading to secondary toxic liver disease or aggravation of cirrhosis. Patients with severe hepatic insufficiency should use drugs correctly under the guidance of a doctor, and prohibit the use of drugs privately, so as not to threaten life.