Multi-organ insufficiency syndrome in the elderly is an important cause of death in elderly patients with critical illnesses. The impairment of body functions leads to a decline in body functions, and the body’s ability to resist infections decreases, and geriatric multi-organ insufficiency syndrome is a manifestation of a decline in the ability to fight infections. What is the prevention of declining resistance to infection? 1.Regular and comprehensive check-ups: At least once a year, elderly people should dynamically monitor the functional indicators of each important organ for early detection of potential diseases. 2.Proactive treatment of primary and chronic diseases: effectively control the progress of the disease and block the development of dangerous pathological processes. 3.For those who already have impaired function of relevant organs, poor nutritional status or low immune function, usually strengthen nutritional support and conditioning of immune function: once there is serious infection, in addition to early anti-infection treatment, timely strengthening of indicators of each organ function monitoring, in order to effectively control the occurrence of MODSE in a timely manner. 4, usually appropriate outdoor exercise, prevention of colds: whenever the winter season, for the elderly in different situations and susceptible people for active protection, can be given in advance nuclear cheese, globulin, vaccination against influenza. Recently introduced a new antigen-free bioimmunomodulatory stimulant Bistiam, can enhance the chemotactic and bactericidal effect of macrophages, and enhance antibody and cellular immune function, has a significant preventive effect on recurrent respiratory tract infections.