There is no absolute best cure for canker sores, and the treatments generally taken are topical medications, oral sensitive antimicrobials, surgical treatments and other treatments. It is recommended that patients with canker sores should go to the hospital as soon as possible. 1. Topical drugs: for patients with mild symptoms, some antibacterial ointment can be used, such as mupirocin ointment; for patients with obvious symptoms, such as swelling, they should follow the doctor’s instructions to assist in the use of magnesium sulfate solution and other wet compresses. 2. Oral sensitive antimicrobials: When patients with carbuncle sores use drugs externally, they can also choose sensitive antimicrobials, such as cefuroxime, according to the results of bacterial culture and drug sensitivity test of the secretions in the affected area, and then take them orally or intravenously. 3. Surgery: If the symptoms of canker sores are serious and pus has appeared in patients, timely surgery is needed to clear the wound and drain the wound, which is conducive to the recovery of the disease. The use of drugs must follow the doctor’s instructions, not blindly use their own medicine, so as not to cause adverse consequences.