Normally, after pregnancy, the ovarian corpus luteum gradually turns into the corpus luteum of pregnancy, and at the same time, progesterone is secreted, which is an important hormone to maintain the progress of pregnancy, and the level of progesterone is an important monitoring indicator during pregnancy. Patients with low progesterone do not need special treatment if their menstruation is normal during the preparation period, but they can take progesterone supplements regularly to adjust their menstruation and improve the condition of low progesterone if they have abnormal menstruation. If the pregnant woman is pregnant and low progesterone levels are found in the early stages of pregnancy, then the next steps need to be taken to choose the treatment according to whether the patient has clinical symptoms or not. First of all, if the pregnant woman has low progesterone level and also has symptoms of vaginal bleeding, usually in this case, it is recommended to consult a local hospital, where a gynecological ultrasound will be performed to clarify the location of the embryo, and after confirming that the embryo is in the uterus, the blood HCG will be checked regularly to understand the development of the embryo, and progesterone supplementation can be given only when the embryo is in normal development. The method of progesterone supplementation can be oral progesterone capsules or intramuscular progesterone injections. The duration of progesterone supplementation will be decided according to the embryo’s development by regular prenatal checkups at the local hospital. In conclusion, the way to prepare for pregnancy with low progesterone needs to be chosen according to the presence or absence of symptoms.