When uterine fibroids and adenomyosis coexist, they should be treated at the same time. If the fibroids are small, they can be treated with pseudo-menopausal method, and if the diameter of fibroids is more than five centimeters and there is no requirement for reproduction, it is recommended to do total hysterectomy. When the fibroid is small, combined with adenomyosis in the clinic can choose the pseudo-menopausal method of treatment, such as the use of danazol to inhibit the growth of ectopic endometrium, resulting in artificial menopause to alleviate the symptoms, if the patient’s symptoms are more pronounced, you can also do total hysterectomy. The drug may have side effects such as breast reduction and acne, and is contraindicated in patients with epilepsy. If the uterine fibroid is relatively large, more than five centimeters in diameter, and the patient has no reproductive needs, a total hysterectomy is recommended, with good postoperative care. If uterine fibroids and adenomyosis are diagnosed as a combined disease, early and standardized treatment is recommended to minimize the adverse effects of the disease.