1, hemolytic jaundice After the massive destruction of red blood cells (hemolysis), the formation of non-conjugated bilirubin increases, and a large amount of non-conjugated bilirubin is transported to the liver, which inevitably increases the burden on the liver (hepatocytes), causing an increase in the concentration of non-conjugated bilirubin in the blood when the uptake and binding capacity of the liver for non-conjugated bilirubin is exceeded. In addition, the anemia caused by massive hemolysis leaves the liver cells in a state of hypoxia and ischemia, and their ability to take up and bind unconjugated bilirubin is bound to be further reduced, resulting in a higher concentration of unconjugated bilirubin in the blood and jaundice. 2, hepatocellular jaundice Due to extensive damage to hepatocytes (degeneration, necrosis), the uptake and binding of unconjugated bilirubin by hepatocytes is impaired, so the concentration of unconjugated bilirubin in the serum increases, while some undamaged hepatocytes can continue to uptake and combine unconjugated bilirubin, turning it into conjugated bilirubin, but part of the conjugated bilirubin is not excreted in the capillary bile ducts, but flows back into the blood through the However, some of the conjugated bilirubin is not excreted in the capillary bile ducts, but flows back into the hepatic lymphatic fluid and blood through the necrotic hepatocyte gap, or the excretion of conjugated bilirubin is blocked by hepatocyte degeneration, swelling, inflammatory lesions in the confluent area and the formation of bile emboli in the capillary bile ducts and small bile ducts, resulting in the overflow of conjugated bilirubin through the small bile ducts (rupture due to increased pressure in the small bile ducts) and back into the hepatic lymphatic fluid and blood, which eventually leads to an increase in the serum concentration of conjugated bilirubin and jaundice. . 4, obstructive jaundice (bile depression jaundice) whether the intrahepatic capillary bile ducts, microscopic bile ducts, small bile ducts, or any part of the extrahepatic hepatobiliary ducts, common hepatic ducts, common bile ducts and lack of special pot belly obstruction or bile depression, the pressure in the bile ducts above the obstruction or depression is constantly increased, the bile ducts are constantly dilated, which eventually leads to the rupture of the intrahepatic small bile ducts or microscopic bile ducts, capillary bile ducts, so that the combined bilirubin overflows from the ruptured bile ducts and flows back into the bloodstream, resulting in jaundice. In addition, some intrahepatic bile depression is not entirely due to mechanical factors such as bile duct rupture (e.g., drug-induced bile depression), but can also be due to reduced bile secretion (secretion dysfunction), increased permeability of the capillary bile ducts, and reduced flow due to bile concentration and stagnation, which eventually leads to bile salt deposition and bile clot formation in the bile ducts.