If alcohol consumption exists in the 24 hours prior to the New Crown vaccination, there is basically no significant effect if the amount of alcohol consumed is small and the alcohol has been completely metabolized in the body prior to the vaccination. However, if a large amount of alcohol is consumed, it is usually not recommended to carry out the vaccination of the new crown vaccine, mainly because a large amount of alcohol may not be completely metabolized before vaccination, and the presence of alcohol in the blood may have the following adverse effects on the organism vaccinated with the new crown vaccine: 1. Affect the effect of the new crown vaccine: after the vaccination of the new crown vaccine, the immune components within the vaccine will stimulate the immune cells to produce antibodies and achieve the preventive effect . If there is alcohol in the blood, it may affect the normal immune function of the human body, thus affecting the stimulation process, resulting in inadequate antibody production and affecting the effect of the new crown vaccine; 2. aggravate the discomfort reaction: most people will have a transient discomfort reaction after receiving the new crown vaccine, and alcohol that has not been completely metabolized will also cause the discomfort reaction of the human body. The combination of the two discomfort reactions may cause an aggravation of the discomfort reaction. There is also the possibility that the stimulation of the immune system by the new crown vaccine under the influence of alcohol may also cause the aggravation of the discomfort reaction; 3. Confusion with the reaction to the new crown vaccine: the human body may experience certain adverse reactions, such as dizziness and nausea, after the new crown vaccination, which may be confused with the discomfort reaction caused by alcohol, easily causing misjudgment of the cause and delaying treatment. Therefore, if you drink alcohol before vaccination, it is recommended that you postpone the vaccination until the alcohol is completely metabolized, if you have enough time to do so. If time is of the essence, you can go to the vaccination site in time, explain the situation to the medical staff and let the professional judge whether you can be vaccinated or take other remedial measures.