I. What is Premature Ejaculation? Premature Ejaculation (PE) is a condition in which a man completes the “process of ejaculation” before he wants to ejaculate during sex, resulting in reduced sexual satisfaction for one or both partners, which can lead to personal distress or interpersonal difficulties. Men with premature ejaculation have a poor ability to control ejaculation, as evidenced by a short latency to ejaculate (IELT). The process of male ejaculation is roughly divided into three periods: the excitement period, the duration period and the waning period. Compared to ordinary men, men with premature ejaculation have less control over ejaculation during sex, cannot effectively control the progress of the “duration” period, have difficulty controlling the rhythm of sex, and cannot obtain a satisfactory latency time for ejaculation in the vagina, thus failing to match the sexual process of both men and women. Premature ejaculation is mainly divided into the following categories: 1. primary premature ejaculation (lifelong premature ejaculation): mainly manifested by premature ejaculation in almost every coitus; with almost every woman; occurring from the first coitus; in most cases (80%) ejaculation in 30-60 seconds, or within 1-2 minutes (20%); will be in rapid ejaculation throughout life (70%) or intensify with aging (30%) ); the ability to control ejaculation is diminished or absent, which is not necessary for diagnosis. 2, secondary premature ejaculation (acquired premature ejaculation): the main manifestation is that premature ejaculation occurs at a number of different times in men’s sexual life; the patient has had a normal ejaculatory experience prior to the discovery of a premature ejaculation condition; this premature ejaculation either appears suddenly or starts slowly; premature ejaculation may be due to other urological diseases or dysfunctions (such as erectile dysfunction or prostatitis), thyroid dysfunction, psychological or interpersonal problems. Unlike primary premature ejaculation, secondary premature ejaculation can be cured by treating the underlying cause. 3, natural variability of premature ejaculation: men just coincidentally or situationally experience premature ejaculation. This kind of premature ejaculation cannot be regarded as a symptom or phenomenon of real pathology, but only a normal variation during sexual activity. The main manifestations are: premature ejaculation does not occur continuously or regularly; the ability to control ejaculation (the ability to control ejaculation of one’s own accord when one feels that ejaculation is imminent) is diminished or absent, which is not necessary for diagnosis; the experience of diminished ejaculation control is accompanied by a short or normal ejaculation time (less than or greater than 1.5 minutes). 4. Premature ejaculation-like ejaculatory dysfunction: It is mainly manifested when the patient experiences or complains of premature ejaculation under the condition of normal ejaculation time (3~6 minutes) or extra-long (5~25 minutes). This type of premature ejaculation cannot be seen as a symptom or phenomenon of a true pathology, and psychological factors or partner relationship problems may be the cause. Symptoms are characterized by the subjective perception of continuous or non-continuous rapid ejaculation during coitus; imagined preoccupation with premature ejaculation or lack of ejaculatory control; actual normal or extra-long IELT; diminished or absent ability to control ejaculation, not necessary for diagnosis; such preoccupation cannot be reasonably explained by other mental disorders. Second, are there many people suffering from premature ejaculation? Premature ejaculation is one of the most common sexual dysfunctions, and studies have found that the prevalence of premature ejaculation is about 31% in the Asia-Pacific region (including China). It is worth noting that premature ejaculation is more common than erectile dysfunction. Research data show that the prevalence of premature ejaculation is similar across all age groups (18-59 years old), which means that the prevalence of premature ejaculation is similar in young and middle-aged and older men. However, the above situation has not attracted much attention from people and physicians. With the continuous improvement of living standards, people have put forward higher requirements for the quality of life, especially for the quality of sexual life has also changed a lot. A person’s disease, involving the “sexual happiness” of two people, if not properly handled, will seriously affect the feelings of the couple and family harmony, and even break the family. Third, do we have premature ejaculation? The main characteristics of premature ejaculation include poor ejaculation control, short ejaculation latency and negative emotional expression. The main expressions are dissatisfaction with sexual life, personal distress and interpersonal disorders, which are also the focus of clinicians’ diagnostic concerns. As an objective evaluation method for clinical symptoms of premature ejaculation, the Premature Ejaculation Diagnostic Tool (Tool for assessing premature ejaculation, Table 1) is recommended by the Chinese Medical Association, Male Branch as an important tool for physician diagnosis and patient self-assessment of premature ejaculation (0~8 points, no premature ejaculation; 9~10 points, premature ejaculation may exist; 11~20 points, premature ejaculation exists): IV. There are many treatments for premature ejaculation, including behavioral therapy, drug therapy, surgical therapy and comprehensive therapy. Most patients with premature ejaculation attempt to prolong the ejaculation latency by turning their thoughts to other aspects such as diet during sexual intercourse in an attempt to delay the ejaculation latency, or by using condoms, drinking alcohol, and other methods. However, these methods are not effective, or lead to reduced sexual desire, reduced sexual pleasure, or even cause erectile dysfunction, which hinders the ability to distinguish sexual sensations and contributes to the aggravation of the condition. Therefore, the treatment of premature ejaculation should first analyze the causes of its onset and choose appropriate treatment methods according to its onset. At the same time, in recent years, the application and research of clinical treatment technology for premature ejaculation has developed rapidly at home and abroad, especially the approval of the first domestic approved drug “Bilirim (Dapoxetine Hydrochloride Tablets)”, which strongly promotes the further development of the application and research of premature ejaculation diagnosis and treatment technology in China, and better provides safe and effective treatment methods for premature ejaculation patients. In general, premature ejaculation is a male sexual dysfunction that is simple to say but actually not simple. When men or partners are dissatisfied with their sexual satisfaction, they should actively seek the help of a professional male physician.