1.Patients with primary trigeminal neuralgia who are ineffective by drug treatment or who cannot tolerate the side effects of drugs. 2, patients with trigeminal neuralgia who are ineffective or relapsed after treatment with closed therapy, radiofrequency thermal coagulation therapy, glycerol destruction, etc. 3, patients who are afraid of open surgery and worried about the complications of surgery are suitable for non-invasive gamma knife treatment. 4, secondary trigeminal neuralgia, the primary lesion has been dealt with, or the primary tumor is small. 5, the elderly, diabetes, hypertension, heart disease and other chronic diseases and poor general health, can not tolerate surgery can choose gamma knife treatment.