”Good news for the doctors, I ate three buns this morning! I don’t want to eat pesticides! I want to live to be 100 years old!” Seeing this 60-year-old smiling like a child, we couldn’t help but smile with relief. The old man, surnamed Zhuang, has been suffering from electric shock-like and knife-like pain on the left side of his face for 5 years, diagnosed as “trigeminal neuralgia”, and has been taking carbamazepine and phenytoin sodium for treatment, which is still effective, only with gum swelling. However, more than 20 days ago, these drugs did not work, and he could not eat, brush his teeth, wash his face, or sleep. The patient’s life was worse than death and she wanted to drink pesticide and die. The patient came to our pain clinic under the protection of her family, and was in extreme pain, very weak and old. After careful examination, there were no abnormal signs of cranial nerve and no abnormalities in the cranial CT, the diagnosis was primary trigeminal neuralgia (branch II), and nerve block treatment could only eliminate the pain for 2 hours. After thorough discussion, it was decided to perform radiofrequency treatment on the patient under local anesthesia. The treatment lasted about 20 minutes, and the patient’s pain was immediately relieved, leaving only a needle hole in the patient’s body. The next morning, the scene at the beginning of this article appeared, and the patient’s expression was different from that before the operation. After 4 months of follow-up, the patient has been off the medication for more than 3 months and has had no more painful episodes. Trigeminal neuralgia is a kind of recurrent paroxysmal severe neuralgia in the distribution area of the facial trigeminal nerve, and is one of the internationally recognized difficult diseases, mostly occurring in middle-aged and elderly people. The disease is characterized by sudden onset, stoppage, lightning-like, knife-like, burning-like, intractable and severe pain within the trigeminal nerve distribution area of the head and face. Patients often do not dare to wipe their faces, eat, or even swallow saliva, thus affecting their normal life and work. Some people call this pain “the first pain in the world”. It can be divided into two categories: primary trigeminal neuralgia and secondary trigeminal neuralgia, of which primary trigeminal neuralgia is more common. The treatment methods for trigeminal neuralgia include medication, nerve block therapy, trigeminal nerve peripheral branch avulsion or adriamycin injection, trigeminal ganglion balloon compression or ethanol destruction, microvascular decompression, gamma knife surgery and radiofrequency therapy. Medication and nerve block therapy can bring pain under control in most patients. However, some patients have poor results and side effects from drug therapy. In contrast, trigeminal nerve peripheral branch avulsion or adriamycin injection, trigeminal ganglion balloon compression or ethanol disruption, microvascular decompression and gamma knife surgery are less commonly used nowadays due to high trauma, high risk and high cost. Trigeminal ganglion (semilunar ganglion) or nerve trunk radiofrequency treatment modulates or denatures the nerve, blocking the pain transmission, thus effectively relieving pain. This treatment technique has been used in foreign countries for many years in a mature manner and has become the preferred minimally invasive treatment for intractable trigeminal neuralgia. Pain radiofrequency technology is considered to be a new technology and a new tool leading the field of pain treatment. Its advantages include: ① precise nerve localization under imaging and neurophysiological monitoring, with exact effect; ② the scope and degree of destruction can be precisely selected and controlled, with little risk and low complication rate; ③ small trauma, percutaneous puncture operation, can be used for outpatients, recovery after treatment is faster than general surgical treatment, and the need for another Radiofrequency does not increase the difficulty of operation when radiofrequency is needed again; ④ operation pain is small; ⑤ radiofrequency treatment pain relief time is long, and radiofrequency treatment can be repeated when pain recurs. The indications for pain radiofrequency treatment are: ① neuropathic pain, such as trigeminal neuralgia, glossopharyngeal neuralgia, pteropalatine ganglion pain, cervicogenic headache, postherpetic neuralgia, intercostal neuralgia, posterior spinal nerve branch pain, perineal pain, certain cancer pain, sympathetic nerve maintenance pain, etc.; ② some intervertebral disc herniation; ③ soft tissue pain, such as frozen shoulder, tennis elbow, fascial pain syndrome, achalasia, etc. Since the introduction of OWL pain radiofrequency treatment instrument made in Canada last year, we have performed radiofrequency treatment for many patients with intractable trigeminal neuralgia, including one patient who was reluctant to undergo the original surgery again after recurrence of other surgical treatment, and all of them achieved satisfactory results without any complications.