The difference between minor triple positive and major triple positive mainly lies in the different clinical significance. Major triple positive refers to the positivity of the first surface antigen, the third E antigen and the fifth core antibody in the five tests of hepatitis B. Minor triple positive refers to the positivity of the first surface antigen, the fourth E antibody and the fifth core antibody in the five tests of hepatitis B. The major triple positive mainly means that the patient is infected with hepatitis B virus with inactive replication, and the patient will not be able to detect the virus in the test. Minor triple positive mainly means that the hepatitis B virus infected by the patient is not active in replication, and the patient will not be able to detect the virus when he/she is tested for hepatitis B virus. In contrast, patients with major triple positive hepatitis B virus replication is relatively more active and the viral results are very obvious. Major Triple Positive is prone to symptoms of hepatitis compared to Minor Triple Positive. Patients with minor triple positive and major triple positive should seek timely medical treatment, follow the doctor’s instructions for examination, and take regular treatment measures under the doctor’s guidance to avoid aggravating their own conditions.