The difference between condyloma acuminatum and pachydermis (pearly papules of the penis) mainly includes medical history, clinical manifestations and laboratory tests. 1. History: Condyloma acuminatum is mainly caused by unclean sex and can be sexually transmitted, while pearly papules of the penis is a normal physiological change, usually related to local irritation, and will not be sexually transmitted. 2. Clinical manifestations: acromegaly can be manifested as granular, cauliflower-like or papillary protuberances, the surface is rough; penis pearl-like papules are smooth surface, size and shape of the regular uniform, usually no bleeding ulcers and other symptoms. 3. laboratory test: acromegaly acetic acid white test positive; and penis pearl-like papules acetic acid white test negative. The new organisms in the external genitalia are recommended to consult a doctor for a clear diagnosis, so as not to delay the condition.