MRSA is the abbreviation of methicillin-resistant Staphylococcus aureus, which refers to Staphylococcus aureus that is resistant to all β-lactam antibiotics and most antibacterial drugs such as macrolides, aminoglycosides and fluoroquinolones, and requires treatment with other more advanced antibiotics, and is one of the common multi-drug resistant bacteria. Its appearance is related to bacterial evolution and misuse of antibiotics, as follows: 1. Distribution and symptoms of MRSA: MRSA can appear in the environment, the human body and other common places, and generally does not infect humans, but infection can occur when there is a decline in immunity, skin breakage or medical invasive operations. It can be divided into community-acquired MRSA and hospital-acquired MRSA. Community-acquired MRSA can occur in the soft tissues of the skin, manifesting as cellulitis and abscesses, and can cause community-acquired pneumonia, septic shock, bone and joint infections; hospital-acquired MRSA often manifests as bacteremia, surgical infections, ulcer surface infections, invasive catheter-related infections, and respiratory-associated pneumonia symptoms; 2. MRSA transmission routes: MRSA mainly occurs in long-term ICU patients, the main transmission routes in the hospital are contact with the hands of medical personnel, other MRSA patients, ventilator tubing and various catheter invasive operations; 3, MRSA hazards: patients infected with MRSA have a certain rate of death, and may prolong the patient’s hospital stay, so once found need timely treatment; 4. Treatment and prevention of MRSA: MRSA is highly sensitive to antibiotics such as vancomycin, teicoplanin, linezolid, and daptomycin, and needs to be treated with different drugs according to the location of the infection. Maintaining good hand hygiene, strict isolation measures and clean environment and equipment can effectively prevent MRSA infection.