(Disclaimer: This article is for scientific use only. To protect patient privacy, the relevant information in the following content has been processed.) Abstract: Patient Wang Lao Han, 58 years old, came to our hospital with a large number of blisters on the right side of his waist, buttocks and outer thighs, accompanied by local burning, pain and numbness. The patient said that in addition to the above symptoms, the knees and feet in the adjacent areas also had knife-like pain although they did not have blisters. Based on the symptoms and the results of routine blood and vesicular fluid PCR tests, the patient was diagnosed with herpes zoster, a viral rash. The patient was cured after a combination of oral medication and topical medication. The patient was treated with oral medication and topical medication. The blisters on the surface of the skin gradually dried up and the pain disappeared I. Initial consultation A 58-year-old patient, Wang Lao Han, came to our hospital and reported that he started to have pain in his right lumbar region 7 days ago. In the next few days, first a small blister grew on the buttock, then similar small blisters appeared on the outer thigh and the back of the waist, and the number gradually increased. There was also a significant cut-like pain in the adjacent part of the knee and waist, accompanied by mild numbness. On examination, the patient was seen to have densely arranged blister-like changes on the posterior side of the waist, right buttock, and right lateral thigh, with flushed local skin, slightly elevated body temperature when touched with the hand, and crystal clear blisters. Based on the clinical presentation alone, the patient was considered to have herpes zoster, which occurs frequently in spring. After communicating with the patient about his condition, the patient agreed to have routine blood and vesicular fluid PCR testing. The routine blood test showed decreased white blood cells and increased lymphocytes, while the vesicular fluid PCR test showed microscopic multinucleated giant cells and intranuclear inclusion bodies. The laboratory findings were consistent with the diagnosis of herpes zoster. The patient agreed to be treated with oral medications and topical medications. Oral vaxilovir hydrochloride tablets as well as vitamin B1, vitamin B6, and vitamin B12 tablets were administered, and topical glyburide lotion with recombinant interferon alpha 2b gel was used. Vaxilovir hydrochloride tablets are oral antiviral drugs that can inhibit the reproduction of the herpes zoster virus in the body and relieve the symptoms of the disease caused by viral infection; vitamin B1, vitamin B6 and vitamin B12 tablets can nourish the nerves and relieve the neuropathic pain caused by the destruction of the nerves by the virus; topical application of furnace glycolate lotion can make the local blisters dry up through the astringent and drying effect; recombinant interferon alpha 2b gel. Recombinant human interferon alpha 2b gel can inhibit the metabolism of the virus from outside to inside, so that the local symptoms can subside as soon as possible. After the patient understood the pharmacological effects of the drug and how to use it, he nodded and said he would go home and take the drug on time, and the patient was instructed to review the drug for 15 days. The patient reported that after 3 days of medication, the new local blisters gradually stabilized and no new lesions appeared, and the pain sensation slightly decreased. The blisters formed on the skin surface gradually dried up after about 7 days of medication, but the pain sensation remained. The pain was relieved around 10 days of medication. As of the day of the review, the number of blisters on the skin surface was significantly reduced and the pain sensation was significantly relieved. On examination, the number of blisters on the patient’s waist, buttocks and outer thighs was significantly reduced, the original blisters gradually dried up, and the surrounding flushed skin gradually returned to flesh color. The patient was instructed to go home and continue to apply medication to nourish the nerves to relieve the pain and promote the local symptoms to subside at the same time, and to continue to review the patient after 15 days. IV. Precautions We are glad that the patient’s discomfort gradually subsided after the drug treatment. Since herpes zoster is a contagious disease, patients should keep a distance from others during the treatment process to avoid infecting them. Pay attention to choosing loose, breathable clothing and avoid picking and scratching, otherwise it may lead to local erosion and exudation, and once combined with bacterial infection, the condition will become more complicated. If the pain symptoms are obvious, you can choose to take oral analgesic drugs under the guidance of a professional doctor to reduce the pain. In addition, pay attention to the full course of therapeutic drugs and do not stop taking them at will. V. Personal insight Herpes zoster itself belongs to a contagious disease caused after varicella-zoster virus infection. Since the virus destroys nerves during the metabolic reproduction process and causes neuropathic pain, this patient indicates that the pain is unbearable. If the treatment is not timely, residual neuralgia may remain, therefore, after the appearance of the above symptoms, you should go to the hospital promptly. Generally antiviral drugs are applied for about 10 days to bring the condition under basic control, and the subsequent nerve-nourishing drugs need to be used in a full course to reduce the duration of pain.