The pathogenesis of spontaneous abortion is complex and involves a wide range of factors, and the pathogenesis is mainly summarized as: genetic factors, reproductive tract abnormalities, endocrine disorders, infectious factors and unknown causes, etc. While sperm as a male conception changes from round to elongated sperm cell nuclei during the process of conception, the sperm nuclei are highly concentrated, forming elongated sperm cells, and enter the epididymis to further mature and form mature sperm, and sperm nucleus protein is The sperm nucleus protein is the main protein of mature sperm. Abnormal morphology of sperm nucleus is one of the main types of morphological abnormalities of sperm. When the rate of sperm abnormality is high, it indicates that there is a transformation disorder of sperm nucleus protein, which may cause abnormal embryo development and lead to spontaneous abortion or malformed baby.