Women who have pain in the urethral opening below holding urine should go to the hospital for examination in time. The pain in the urethra below the female holding urine is usually due to inflammation of the urinary system, gynecological inflammation, bladder and urethra lesions, malignant tumors and other reasons, as the causes of pain in the urethra are different, the appropriate treatment measures should be taken according to the specific situation, but it should be noted that all drugs need to be used under the guidance of a doctor. 1, inflammation of the urinary system: women will have symptoms of frequent urination, urinary urgency, painful urination, can be used under the guidance of a doctor Under the guidance of the doctor to use antibiotics to anti-infection treatment, clinically commonly used levofloxacin, fosfomycin, cefdinir, azithromycin, cefixime, etc.. Women can also choose furantoin and other drugs, also has a certain effect, at the same time should pay attention to drink more water, do not eat spicy, stimulating food, prohibit alcohol; 2, gynecological inflammation: such as vaginitis, cervicitis, pelvic inflammatory disease, etc., can also induce holding urine below the urethral pain, such pain is usually due to the surrounding organs and tissues radiated, generally should be actively treated the original disease, such as pelvic inflammatory disease, vaginitis, cervicitis, etc.. Through oral antibiotics as well as local topical medication, gynecological inflammation can be cured and the symptoms of urethral pain will be reduced or disappear, such as vaginitis can be treated locally with metronidazole suppositories, clotrimazole suppositories and other drugs, cervicitis and pelvic inflammatory disease can be treated with penicillin or ceftriaxone, etc.; 3. Bladder and urethral lesions: women holding urine below the urethral orifice pain, there may also be bladder stones, ureteral end stones, the bladder as well as urethral injury, etc. Women should undergo lithotripsy treatment, such as extracorporeal lithotripsy or surgical lithotripsy, for the size and location of the stones, and the symptoms of pain in the urethra when holding urine will improve after treatment. If there is damage to the bladder and urethra, you can usually leave a catheter in place first, the wound can be initially healed after 1-2 weeks, if the damage is more serious, surgery is required; 4, cystitis: women suffering from cystitis will also appear to hold urine below the urethral pain, cystitis is not caused by infection, oral antibiotics usually have no effect, you can target the use of some symptom relief drugs, you can use M receptor blockers such as tolterodine, solifenacin, etc., or beta3 receptor stimulants, such as mirabellum, etc., can relieve pain in the urethra due to interstitial cystitis. Severe female patients can also take oral analgesic drugs, such as ibuprofen extended-release capsules, etc.; 5. Malignant tumors: If a woman suffers from malignant tumors such as bladder cancer, urethral cancer, vaginal cancer, cervical cancer, etc., which invade the urethra, it will also lead to pain in the urethral orifice below holding urine. At this time, surgery, chemotherapy, radiotherapy and other programs should be used according to the different stages and grades of the tumor. By treating the primary disease, the symptoms of pain in the urethra below holding urine for women may also be improved. If women have symptoms of painful urethral opening under holding urine, it is recommended to go to the hospital for routine urine examination and then follow the medical advice for targeted treatment. Women should also pay attention to drink more water in their daily lives, avoid holding urine, and ensure sufficient sleep to avoid inducing uncomfortable symptoms.