Infertility caused by the side effects of drugs is medically known as pharmacogenic infertility. According to statistics, 4-6% of infertility is caused by drugs. The drugs that may cause pharmacogenic infertility are as follows: Sulfa drugs: such as cotrimoxazole is commonly used to treat urinary tract infections, respiratory tract infections, etc. Its side effects in fertility are inhibition of testicular function, resulting in a significant reduction in the number of sperm and a significant decrease in sperm motility. Antibiotics: Furacilin and its derivatives can inhibit carbohydrate metabolism and oxygen consumption in testicular cells, causing a decrease in DNA concentration in spermatogenic cells, resulting in a decrease in spermatozoa and infertility. Macrolides, such as erythromycin and spiramycin, cause cessation of sperm development and reduced mitosis, causing sperm to be killed or killed, and the surviving sperm to be significantly less active. Aminoglycosides block the meiosis of the initial spermatocytes, so they affect spermatogenesis. Methandiamide: This drug is used in the treatment of duodenal ulcer, and large amounts of continuous use can cause a decrease in sperm count. Antineoplastic drugs: Bad phosphoramidite is a commonly used anticancer drug, and when the total amount reaches 6-10 grams per day, it can cause a significant decrease in sperm count and even azoospermia. Women may experience menstrual cycle disorders. Tumorconine (benzoylecgonine) has toxic side effects on the gonads. 80% of adolescent patients with the drug will develop oligospermia, and irreversible oligospermia or azoospermia will occur if the total amount of drug used by the patient exceeds 25 mg/kg. Hormones: Long-term application of excessive steroid hormones can inhibit the function of the hypothalamic-pituitary-testicular axis in males, resulting in reduced sperm production due to testicular atrophy. The use of estrogen can cause impotence, delayed ejaculation and inability to ejaculate in men. The use of adrenocorticotropic hormones can cause loss of orgasm, menstrual disorders and amenorrhea in women, and androgens can cause delayed menstruation, hypersexuality and masculinization in women. Anti-hypertensive drugs: Lipiodol can reduce libido. Long-term use of anti-hypertensives can affect pituitary function and inhibit sperm production to reduce sperm or even no sperm production. Anti-hypertensive drugs, insulin, methyldopa, etc. can cause decreased libido, menstrual disorders and non-ejaculation. Sedative sleeping pills: long-term use or abuse of barbiturates and non-barbiturate sedative sleeping pills can cause menstrual disorders and ovulation disorders in women. Men may experience decreased libido, impotence, or loss of orgasm. Chlorpromazine causes a decrease in estrogen and androgen secretion, which can lead to impotence, ejaculation difficulties, testicular atrophy and gynecomastia in men; abnormal menstruation and amenorrhea in women. When applied in larger doses, Librium and Valium can cause impotence in men and menstrual disorders and ovulation disorders in women. Narcotic and analgesic drugs: morphine, dulcolax, heroin, etc. can interfere with the regulatory process of the hypothalamic-pituitary system, causing ejaculation disorders and leading to infertility.