Intrauterine infections are important infectious factors that can harm the brain development of babies before birth. The common causative pathogens are toxoplasma, rubella virus, cytomegalovirus, herpes virus and other infections. Common pathogenic microorganisms of intrauterine infections Rubella virus and cytomegalovirus infections often cause fetal developmental malformations in the third trimester of pregnancy, especially teratogenic effects on the brain, so they are also known as teratogenic viral infections. Toxoplasma gondii and herpesvirus infections can cause fetal brain damage throughout pregnancy. Other infections are mainly syphilis and HIV infections. Intrauterine infections, especially in early gestation, often cause fetal brain hypoplasia and defects, resulting in microcephaly or microcephaly. As a result, postnatal infants often develop sequelae such as microcephaly, hydrocephalus, mental retardation and cerebral palsy, mainly tetraplegia. Chorioamnionitis Another important infection is chorioamnionitis caused by bacteria and mycoplasma. It often causes premature birth and increases the risk of cerebral palsy in preterm or term infants. Studies have shown that approximately 11% of children whose mothers have chorioamnionitis develop cerebral palsy. in preterm infants, chorioamnionitis is significantly associated with cerebral palsy and cystic periventricular leukomalacia. Clinically, it presents with spastic biparesis. Amniocentesis has shown increased concentrations of tumor necrosis factor-α, interleukin-1β, and interleukin-6 in amniotic fluid in the presence of cystic periventricular leukomalacia. Prevention and control of intrauterine infections It is important to perform appropriate serological tests during pregnancy and neonatal period of the mother, as timely treatment of these infections, especially Toxoplasma gondii, is of great importance to prevent the diseases caused by them, such as cerebral palsy.