HPV + liquid-based cytology is a routine IUI/IVF/ICSI pre-procedure test. Some patients have this question: The report shows HPV infection, so can I continue to prepare for pregnancy? Do I need treatment? Today we will learn more about the relationship between HPV and infertility. What is HPV? Human papillomavirus (HPV) is an envelope-free double-stranded DNA virus with more than 200 genotypes, divided into high-risk/oncogenic (HPV 16, 18, 31, 33, 35, 39, 45, 5l, 52, 53, 56, 58, 59, 66 and 83) and low-risk/non-oncogenic (HPV 6, 11, 42, 43, 44 and 81). , 43, 44, and 81, etc.). High-risk types can cause cancer in the vulva, vagina, cervix, and anus, while low-risk types can cause benign lesions such as condyloma acuminata and flat warts on the skin. HPV infection is very common, the international report of sexually active women of childbearing age HPV infection rate of 50%, in 2012 China’s 37 cities of women aged 20-40 years HPV infection rate is stable at about 20%, and infertile women HPV detection rate is higher than the same age group of fertile women. Men can also be infected with HPV! The detection rate of HPV in the semen of fertile men is also about 20%. The primary mode of transmission of HPV is sexual. In addition, indirect contact (contact with underwear, underpants, bath towels, toilet seats, etc.) and mother-to-child transmission can also lead to HPV infection. HPV often manifests as a transient infection, and 90% of immunocompetent individuals can clear HPV within 2 years. 2. Relationship between HPV infection and infertility: Although the current female HPV test specimens are mainly from cervical brushes, there is evidence that HPV can be detected in the endometrium and ovaries, indicating that HPV can be infected upstream from the cervix and may have an impact on reproductive system function: follicular fluid and eggs HPV infection Section affects fertilization, oogenesis, early embryonic development and implantation, resulting in low clinical pregnancy rates for HPV(+) under equivalent conditions. In men, semen HPV infection leads to a decrease in sperm quality: concentration, percentage of forward motion, and normal morphology sperm rate are significantly reduced, and sperm DNA fragmentation rate is significantly higher. However, routine semen washing in assisted reproductive technologies may help to remove HPV from sperm. Due to the sampling relationship, there is no consensus on the relationship between cervical HPV infection and female infertility. Since the vast majority of HPV(+) infertility patients are high-risk infections, the available studies can only suggest that HPV high-risk infection may be a risk factor for female infertility. 3. What should I do if I am HPV positive? The principle of treatment is “treat the disease, not the virus”. If the HPV is positive, and the liquid-based cytology does not show atypical hyperplasia, intraepithelial neoplasia, cancer, etc., no visible lesions (such as condyloma acuminata), the virus is a carrier state, no treatment is needed, regular review can be done. If there are visible lesions or lesions on pathological examination, the lesions need to be treated and treated. There is no specific drug for HPV and vaccine is used for prevention. Therefore, if there is a lesion, treat it and consider further pregnancy planning after it is cured; if there is no lesion, continue with the next pregnancy planning and pay attention to regular review.