Adults with yellow nasal discharge and yellow sputum are commonly due to upper respiratory tract infections, and antibiotics, vasoconstrictors, and expectorants can be chosen according to the condition. 1. Antibiotics: adults with upper respiratory tract infections, if the symptoms of yellow sputum and yellow nasal discharge are considered to be caused by bacterial infections, it is feasible to culture the secretions, and according to the drug sensitivity test, select amoxicillin, levofloxacin, and other sensitive antibiotic treatment. 2. Vasoconstrictor: yellow nasal discharge, yellow sputum, mostly combined with nasal mucosal congestion and edema, nasal congestion and other symptoms, can be applied to pseudoephedrine hydrochloride and other symptomatic reduction of secretion exudation. 3. Expectorant drugs: When patients cough up more phlegm, they can choose expectorant drugs for treatment, such as Ambroxol hydrochloride, acetylcysteine and other drugs. There are many other causes of yellow nasal mucus and phlegm in adults, and it is necessary to improve the relevant laboratory tests to clarify the cause of the disease and give targeted treatment, and the above drugs need to be standardized and rationally applied under the guidance of professional physicians and pharmacists.