Patients with abdominal pain accompanied by nausea and the urge to vomit can apply metoclopramide injection intramuscularly in this case, which can relieve the symptoms of nausea, or choose 5-hydroxytryptamine receptor antagonists, including ondansetron and toltesetron for intravenous injection, which can significantly relieve the patient’s symptoms. For patients with abdominal pain with nausea, the etiology should be clarified in detail, and if it is caused by an infectious source, anti-infective, symptomatic, rehydration and other supportive treatments should be actively administered. For primary abdominal cavity lesions, including appendicitis or cholecystitis, the most effective treatment in this case is to opt for surgical removal of the appendix or removal of the gallbladder, which should also be followed by active anti-infective, intravenous fluid replacement and other symptomatic treatment. The most common symptom of intra-abdominal organ disease and inflammation is abdominal pain, which is easily accompanied by nausea and vomiting.