At 40 years old, premature ejaculation can still be cured, the main drug treatment, psychological counseling and sexual health education, physical therapy and so on. 1. Medication: Dapoxetine hydrochloride can be preferred, as well as long-acting selective 5-hydroxytryptamine reuptake inhibitors such as sertraline and paroxetine, etc. In addition, phosphodiesterase-5 inhibitors such as sildenafil and vardenafil also have good efficacy. 2. Psychological counseling and sexual health education: the use of psychological, skills counseling and drug combination of integrated treatment methods, but also need to be the two sides of the same diagnosis and treatment and tracking treatment feedback. Those with anxiety and depression need psychiatric treatment. 3. Physical therapy: pelvic floor rehabilitation training, penis root training behavioral therapy, etc., can also use biofeedback and other physical therapy. If you are 40 years old and have premature ejaculation, you need to follow the doctor’s instructions to receive standardized treatment, not self-treatment, so as not to delay the condition.