Pulmonary embolism (PE) has a variety of clinical manifestations, which may be asymptomatic in mild cases or manifest as hypotension, shock, or even sudden death in severe cases. The common clinical symptoms include dyspnea, chest pain, hemoptysis, syncope, etc. They can appear separately or together. That is, 97% of PE patients who used to have no cardiopulmonary disease have dyspnea, shortness of breath, syncope or chest pain. 1.The rapid appearance of simple dyspnea is often caused by PE near the center (not affecting the pleura); sometimes, dyspnea manifests itself as a progressive worsening over several weeks, so the possibility of pulmonary embolism (PE) should be thought of for progressive dyspnea with no other explanation; for patients with previous heart failure or pulmonary disease, worsening dyspnea may be the only symptom suggesting PE. 2. There are two types of chest pain: pleuritic chest pain and angina-like chest pain. Pleuritic chest pain is more intense, has a clear location, is related to respiratory movements, and is a common clinical manifestation of pulmonary embolism. This pain is caused by the distal embolus irritating the pleura. Some patients show angina-like chest pain in the form of retrosternal chest pain, the nature of which is not clear and may be related to right ventricular ischemia. 3. Syncope and shock are characteristic of patients with central pulmonary embolism (PE) combined with severe hemodynamic disturbances, and clinical signs of arterial hypotension in the body circulation, oliguria, extremity chills, and/or acute right heart failure. 4. Physical examination may reveal signs of pulmonary hypertension P2 hyperactivity, systolic murmur in the pulmonary valve area, etc.) signs of increased right ventricular load, and some patients may have pleural effusion or pulmonary lesion manifestations. 5.Deep vein thrombosis in the lower limbs is the sign of PE, and the physical examination shows asymmetric edema in both lower limbs, deep vein area pressure pain, superficial varicose veins, buttock stiffness and pigmentation, etc. The prognosis is better for non-pulmonary embolism (PE) without hemodynamic disturbance and right heart insufficiency. 7, pulmonary embolism (PE) is easily misdiagnosed as coronary artery disease; acute myocardial infarction; angina pectoris; heart failure; pleurisy, etc. The possibility of pulmonary embolism (PE) should be thought of when dyspnea manifests itself as progressive worsening within weeks, progressive dyspnea without other explanations, hypoxemia, syncope, hypotension, and shock.