Amoxicillin is a broad-spectrum antibiotic, so it is effective for anti-inflammatory and pain relief during toothache. It is also recommended to combine with metronidazole tablets to reduce inflammation, so that the anti-inflammatory effect will be good. In addition, for patients with toothache, it is recommended to seek timely medical treatment and symptomatic treatment in order to solve the problem at root, most of the toothache is caused by caries, pulpitis, periapical inflammation, pericoronitis of wisdom teeth and other diseases. Patients with dental caries should have resin filling treatment for dental caries in time, and patients with pulpitis and periapical infection should have root canal treatment to remove the infected pulp nerve in order to stop the pain completely. For patients with wisdom tooth pericoronitis, it is recommended to perform rinsing and medication of wisdom tooth pericoronitis in order to prevent the recurrence of pain.