Cytomegalovirus infection is a sexually transmitted disease caused by cytomegalovirus (cmv). Cytomegalovirus is a DNA virus. The characteristic lesions are enlarged infected cells with eosinophilic and basophilic inclusions in the nucleus and cytoplasm, respectively.CMV infection is distributed worldwide and humans are the only host of CMV. The rate of infection varies by country and economic status. There is a close relationship between CMV infection and immune function in adults. How is enlarged cellular infection diagnosed? The clinical manifestations of the disease vary in severity systemic giant cell inclusion body disease mainly occurs in newborns and young infants so jaundice hepatosplenomegaly, skin petechiae, microcephaly, and intracranial calcification are seen. The diagnosis of CMV infection cannot be made by clinical manifestations alone. Isolation of the virus from clinical specimens, along with a 4-fold or more increase in antibody presentation or a sustained increase in antibody titers, will aid in the diagnosis. 1, virus isolation is best to use saliva, urine, reproductive tract secretions, milk and leukocytes, inoculated into human fibroblasts to multiply and isolate, cytopathic effect (CPE) in 1 day or several weeks, after fixation and HE staining can be observed in giant cells, nuclear inclusions, perinuclear halo and eosinophilic intracytoplasmic inclusions, much like “owl’s eye “(owl′seye) can also be examined by fluorescent staining with monoclonal or polyclonal antibodies. 2, serum antibody detection cellular infection increases the most commonly used complement binding test (CF), indirect immunofluorescence test (IIF), immunoenzymatic assay (EIA), indirect hemagglutination test (IHA) and radioimmunoassay (RIA) to detect CMV-IgG and IgM antibodies. When a single serum specimen has identified previous CMV infection, serum specimens should be kept immediately, as well as at intervals of 2 weeks, 4 weeks, and 8 weeks, combined with virus isolation can be used for the diagnosis of primary infection. 3, DNA probes have been widely used to detect CMV, with the 32P-labeled probes having the highest sensitivity, and for some specimens, hybridization methods may be more sensitive than viral isolation. 4, polymerase chain reaction (PCR) The treatment of cytomegalovirus infection can be applied to a variety of antiviral agents such as GCV, anti-cytomegalovirus immunoglobulin agents, interferon and transfer factor. However, these drugs do not solve the underlying problem, and often the virus rises again latently after stopping the drugs. In view of the fact that this virus may serve as one of the causes of AIDS, scholars from various countries are devoted to the research of controlling its infection. Recently, American scholars have developed two live vaccines, which have been effective after initial trials. One is developed from AD169 strain; the other is made from TOWN strain, and after non-intestinal administration, it has clearly shown anti-cytomegalovirus efficacy and elevated CMV antibodies, leading to enhanced immune function.