Pimples on the soles of the feet with itching is seen in the clinic for a variety of reasons, commonly in the three diseases of tinea pedis, eczema, and sweating, and commonly in those with damp and sweaty feet and poor hygiene. 1. Tinea pedis: It is mainly caused by fungal infections and can be accompanied by local skin reactions such as erythema, desquamation, blistering, and erosion in addition to the itching of pimples on the soles of the feet, and the fungus can break down the keratin layer during its activity, making itching intense. Need to go to the hospital for local fungal examination, after the diagnosis can choose to treat with topical antifungal drugs, such as bifenazole cream, terbinafine cream, etc. During the treatment period, you need to avoid wearing damp and stuffy shoes and socks, otherwise it is easy to promote fungal reproduction and affect the treatment effect, usually need to pay attention to personal cleanliness and hygiene, and develop good living habits; 2, eczema: humidity, stuffiness or allergies and other factors acting together on the soles of the feet can lead to eczema-like disease, which can be manifested as pimples and itching on the soles of the feet, but also with erythema, papules, blisters, vesicles, oozing and other clinical symptoms. Laboratory fungal tests are negative. Glucocorticoid creams, such as Pirexone ointment, and oral anti-allergy medications, such as cetirizine, can be used to treat the condition. It is necessary to pay attention to not to wear tight fiber footwear, keep the feet breathable, diet should be light, avoid spicy stimulating food; 3, sweating herpes: the cause and pathogenesis of this disease is still unclear, may be a kind of occurrence in the skin eczema-like hypersensitivity reaction, mental factors, focal infection, local allergy (nickel, chromium metal allergy) or stimulation, allergic constitution and neurological dysfunction may be related to the production of this disease, some patients have a family history. Some patients have a family history. The typical lesion is a diffuse distribution of small deep blisters on the palmoplantar, flexural side of the fingers and toes, and between the fingers of both hands and feet, the size of a pinhead to a grain of rice, with thick walls, transparent herpes, itching or burning pain, accompanied by sweaty hands and feet, no obvious inflammatory reaction, the blisters usually do not rupture on their own, about 2-3 weeks later can be absorbed and dried up to form peeling, revealing a thin red fresh epidermis, at this time there is a painful sensation. The course of the disease lasts for several weeks or months, can be self-healing, but easy to recur. Patients need to pay attention to the hygiene of the affected area and avoid excessive sweating of the hands and feet caused by factors such as mental stress, and can also be treated with medication under the guidance of a doctor.