1, there is no significant difference in pregnancy rate between IVF with normal semen and ICSI treatment, but because ICSI is an invasive treatment, it is limited to necessary users. 2, ICSI treatment effectively improves the fertilization rate of few, weak and deformed sperm, but it has been confirmed that some hereditary genetic defects can lead to few and weak sperm, genetic defects that would have been eliminated during natural fertilization can be passed to the next generation through ICSI, and the injection operation may also lead to unknown damage to the oocyte. 3, women who become pregnant after ICSI treatment should strengthen the follow-up during pregnancy and after delivery to understand the offspring.