Primary premature ejaculation can be treated by medication (such as local anesthesia drugs, 5-hydroxytryptamine reuptake inhibitors, etc.) and surgery, etc. In general, primary premature ejaculation can be cured, but the cure rate is low. 1. Drug treatment: (1) local anesthetic drugs: can reduce the sensitivity of the penis, prolong the ejaculation time, commonly used drugs are lidocaine, benzocaine, etc.. (2) 5 hydroxytryptamine reuptake inhibitor: is commonly used antidepressant drugs, the treatment of primary premature ejaculation has a certain effect, commonly used drugs are dapoxetine, paroxetine, sertraline and so on. 2. Surgery: When conservative treatment is ineffective, surgery such as dorsal penile nerve selective cutting can be chosen to improve the patient’s sensory threshold and prolong the ejaculation time. Primary premature ejaculation is generally not self-healing, but most patients can improve their symptoms through standardized treatment, and a small number of patients can be cured after treatment, it is recommended that patients go to the hospital in a timely manner, follow the doctor’s instructions for standardized treatment, so as not to affect the quality of life. The above drugs need to be used under the guidance of a professional physician, to avoid blind use of drugs, so as not to aggravate the condition.