Insulin injection pens can be divided into insulin injection pens with special refills and insulin injection pens with replaceable refills. The insulin pen is a disposable injection device that is pre-filled with 3ml (including 300U) of insulin and does not require a refill and is discarded after use. The refillable insulin injection pen consists of an injection pen and an insulin refill. Once the insulin in the refill is used up, it needs to be replaced with a new refill, while the injection pen can be reused. However, at present, the insulin injection pen of the same brand can only be used with the same brand of insulin, and there are some differences in its usage. Gao Hongjiao insulin injection pen of the Department of Endocrinology of the First People’s Hospital of Zunyi City is marked with a dose scale, and the needles used for its injection pen are very small, thus reducing the pain and the mental burden of patients during injection. In addition, the insulin injection pen is easy to use and portable, and is very suitable for insulin treatment regimen of multiple times a day. However, since different insulins cannot be mixed, when different types of insulin are used, they cannot be freely rationed, and unless premixed insulin is used, two separate injections are required, which has certain limitations. There are differences in the absorption of insulin by different tissues in the body. When insulin is injected subcutaneously, the maximum absorption peak occurs in 1 to 2 hours, the rise and fall of the absorption curve is more gentle, and the effect of insulin is more stable and long-lasting. When the insulin is injected intramuscularly, the absorption characteristics of insulin are very different: the insulin level rises sharply, the peak appears too early, and the effect of insulin disappears too quickly and does not last as long as it should. In addition, the insulin absorption status of resting and exercising muscles is also very different. Therefore, insulin should be injected subcutaneously. It is crucial to choose the right length needle for pen injections. A variety of factors such as the patient’s physical condition, pharmacology and psychology should be fully considered to make an individualized selection for the patient. Recommendations: 1. Before injection, to ensure smooth passage of the drug and to eliminate dead space in the needle, push the injector pen button according to the manufacturer’s instructions to ensure that at least one drop of drug hangs on the needle tip. 2. Each set of injector pens and refills should be used for one patient only and should never be shared between patients. 3. To prevent air or other contaminants from entering the refill and drug leakage, the needle of the injector pen should be discarded after use with the outer needle cap on and should not be left on the injector pen. 4. 4. After the thumb button is fully depressed, the needle should be left in place for at least 10 seconds before being withdrawn to ensure that the full dose is injected and to prevent leakage of the drug. For larger doses, more than 10 seconds is necessary. 5. The needle of the injection pen should be used only once. The above content is from the WeChat subscription number “Zunyi Diabetes Education Window”. You can join by searching for the micro signal “zytnbw” in WeChat “Add Friend”, or you can directly “sweep” the above WeChat QR code to join.