Multiple cerebral ischemic foci are mainly caused by the blockage of capillaries in the brain, resulting in the formation of hollow blood vessels, which prevent blood flow and cause localized ischemia, hypoxia and necrosis of brain cells. Clinically, it is usually a small cerebral vascular lesion, which can be seen in patients with hypertension or diabetes and is mainly caused by atherosclerosis. Multiple ischemic foci in the brain can also be seen in patients with a history of migraine headaches, mainly due to prolonged spasm of small blood vessels in the brain, resulting in interruption of blood supply to the brain capillaries. In addition, multiple ischemic foci can also be seen in patients with congenital foramen ovale, especially when the foramen ovale is relatively small and stimulated by microemboli. If the patient presents with focal neurological deficits, the cause should be investigated if necessary, and the patient should be monitored for microemboli by foaming tests and, if necessary, by esophageal ultrasonography.